As a part of an innovative aerodynamic design concept for a single stage low pressure turbine, a high turning outlet guide vane is required to remove the swirl from the hot gas. The airfoil of the vane is a highly loaded compressor airfoil that has to operate at very low Reynolds numbers (). Recently published numerical design studies and experimental analysis on alternatively designed airfoils showed that blade profiles with an extreme front loaded pressure distribution are advantageous for low Reynolds number conditions. The advantage even holds true for an increased inlet Mach number at which the peak Mach number on the airfoils reaches and exceeds the critical conditions . This paper discusses the effect of the inlet Mach number and Reynolds number on the cascade performance for both a controlled diffusion airfoil (CDA) (called baseline) and a numerically optimized front loaded airfoil. The results show that it is advantageous to design the profile with a fairly steep pressure gradient immediately at the front part in order to promote early transition or to prevent too large laminar—even shock induced—separations with the risk of a bubble burst. Profile Mach number distributions and wake traverse data are presented for design and off-design conditions. The discussion of Mach number distributions and boundary layer behavior is supported by numerical results obtained from the blade-to-blade flow solver MISES.