In the present study the flow and heat transfer in a tandem cylinder setup are simulated by means of embedded direct numerical simulation (DNS). The influence of wake turbulence on the heat transfer in the stagnation region of the rear cylinder is investigated. The oncoming flow is varied by increasing the distance between the two cylinders, causing a change of the turbulent wake characteristics and the heat transfer. The data of both simulations show good agreement with an existing experimental correlation in the literature. For the small wake generator distance, a clear shift of the maximum heat transfer away from the stagnation line is observed. This shift is less pronounced for the larger distance.