The present paper deals with the numerical and experimental investigation of the effect of return channel (RCH) dimensions of a centrifugal compressor stage on the aerodynamic performance. Three different return channel stages were investigated, two stages comprising three-dimensional (3D) return channel blades and one stage comprising two-dimensional (2D) RCH vanes. The analysis was performed regarding both the investigation of overall performance (stage efficiency, RCH total pressure loss coefficient) and detailed flow-field performance. For detailed experimental flow-field investigation at the stage exit, six circumferentially traversed three-hole probes were positioned downstream the return channel exit in order to get two-dimensional flow-field information. Additionally, static pressure wall measurements were taken at the hub and shroud pressure and suction side (SS) of the 2D and 3D return channel blades. The return channel system overall performance was calculated by measurements of the circumferentially averaged 1D flow field downstream the diffuser exit and downstream the stage exit. Dependent on the type of return channel blade, the numerical and experimental results show a significant effect on the flow field overall and detail performance. In general, satisfactory agreement between computational fluid dynamics (CFD)-prediction and test-rig measurements was achieved regarding overall and flow-field performance. In comparison with the measurements, the CFD-calculated stage performance (efficiency and pressure rise coefficient) of all the 3D-RCH stages was slightly overpredicted. Very good agreement between CFD and measurement results was found for the static pressure distribution on the RCH wall surfaces while small CFD-deviations occur in the measured flow angle at the stage exit, dependent on the turbulence model selected.