PLLA is a commonly used biodegradable polymer in stent designs because it is non-toxic and easily eliminated from the body. However, very little is known about the effect of loading conditions on the degradation rate. Rajagopal and Wineman developed a model of polymer degradation which is driven by load applied to the fiber . Soares et. al. further developed this model for use with PLLA stent fibers under tensile loading conditions . In this model the degradation rate is linearly related to deformation through the radius in the (IB, IIB) plane. Both models predict that greater deformation will induce a higher degree of degradation.
- Bioengineering Division
The Effect of Static and Dynamic Loading on Degradation of PLLA Stent Fibers
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Hayman, D, Bergerson, C, Miller, S, Moreno, M, & Moore, JE, Jr. "The Effect of Static and Dynamic Loading on Degradation of PLLA Stent Fibers." Proceedings of the ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. Washington, DC, USA. September 11–13, 2013. V001T10A039. ASME. https://doi.org/10.1115/FMD2013-16149
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