In this technological era, Unmanned Aerial Vehicle (UAV) has evolved drastically and various research in propulsion and propellers are going on. Large diameter-based propellers with good cum relevant pitches are best suited for carrying heavy payloads and to improvise the aerodynamic along with the structural performance of these propellers, the FSI technique has been implemented. It is necessary to consider the oscillatory effects in structures that may be resulting in the lifespan of the propellers. Therefore, the user-friendly cum advanced computational tool is mandatory to execute these aforesaid effects. A suitable tool to compute the Rotodynamic with Aerodynamic effects on 10 and 20 inches based propellers is found out, which is ANSYS Workbench. The unique design approach has been implemented in this work to construct various high payload-based UAV’s Propellers. Ten different propellers are designed through analytical calculation and thereby the modeling of all the propellers is completed in CATIA. Thereafter, the complicated Rotodynamic analysis is computed through ANSYS FLUENT, in which MRF (Moving Reference Frame) approach is imposed for the representation of real-time behavior. Additionally, the transient structural simulations are carried out on shortlisted UAV’s Propellers, and thereby the suitable Propeller is given as the best performer for high payload application. Based on high thrust production, low reacted deformation, and low induced equivalent stress, the Propeller is chosen which can maneuver with all kind of environmental conditions.