The temperature dependence of the rate of denaturation of Type I collagen due to heating is described well by chemical kinetics via the Arrhenius equation or transition state theory (TST) [1, 2, 3], each of which requires two material parameters. Nevertheless, many have sought to find a single convenient metric, such as one with units of temperature, to describe thermal denaturation of collagen. Comparing the results of studies that measured denaturation and cell death for a variety of biological samples shows that the parameters for either the Arrhenius equation (i.e. activation energy Ea and the frequency factor A) appear correlated over the range of temperatures for which biological materials are tested [4]. It has also been suggested that denaturation is a first-order phase change (i.e., melting) and thus should be characterized by a melting or denaturation temperature Td [5].

This content is only available via PDF.
You do not currently have access to this content.