An anteroapical transmural myocardial infarction was created in Dorset sheep and resulting scar tissues were excised two (Group A, n=5, 10.6 ± 1.2 weeks) and eight months (Group B, n=6, 36.8 ± 1.4 weeks) post infarction [1]. Samples were oriented in longitudinal and circumferential directions in a biaxial stretcher, preconditioned and tested in displacement control at room temperature in BDM solution. Stress-strain plots were obtained for samples. Histology was performed by cryo-sectioning specimens into 8 μm slices and staining using Hematoxylin & Eosin. Stress-strain analyses show that circumsferential direction was stiffer than longitudinal for Group A. Group B samples show a reverse trend and are stiffer than Group A. Stained sections show more collagen in the endocardial surface for Group B samples while Group A samples have added collagen in the epicardial side. A high density of fat cells was seen in Group B samples that may affect stiffness trends.

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