The use of Ti-6Al-4V for spinal implants has increased due to its advantageous mechanical properties, biocompatibility, corrosion resistance, and compatibility with MRI procedures. The release of metal ions or particulates, which can result from mechanical loads imposed on the implant, can affect the degree of biocompatibility of spinal implants, possibly influencing their clinical performance. In this project, the titanium metal release from Ti-6Al-4V posterior cervical spine plates was examined using a computational and experimental approach in the canine model.

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