In the early year of this century the human genome sequencing project was successfully completed so that we can understand all the human genes and their corresponding protein sequences. Now our interests have naturally moved from genetics to proteomics in which we challenge to elucidate the relationship between functions and structures of proteins. In particular, understanding large conformational changes occurring at molecular machinery systems or protein assemblies have received great attentions. However, it has been rarely studied both experimentally and theoretically because of limitation of experimental setup for capturing real time protein dynamics and computing power, respectively.

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