Offshore wind system encountered wind, wave, current, soil, and other environmental loads. The support structure is randomly loaded for a long time, which is more likely to cause fatigue damage. In this paper, the NREL 5MW wind turbine and OC4 jacket support structure is selected to perform the time domain fatigue analysis. Commercial software Bladed and SACS are used to perform the required structural responses and fatigue strength calculations. The Stress Concentration Factors (SCF) and S-N curves for the stress calculations of tubular joints are adopted based on the recommendation of DNV GL guidelines. The magnitude of the stress variation range and the corresponding number of counts are obtained by using the rain-flow counting algorithm. Finally, the Palmgren-Miner’s rule is adopted to calculate the cumulative damage ratio and the fatigue life can then be estimated. Fatigue damage ratio and structural fatigue life of each joint during 20 years of operation period are evaluated.