Minimum miscibility pressure (MMP), as a key parameter for the miscible gas injection enhanced oil recovery (EOR) in unconventional reservoirs, is affected by the dominance of nanoscale pores. The objective of this work is to investigate the impact of nanoscale confinement on MMP of CO2/hydrocarbon systems and to compare the accuracy of different theoretical approaches in calculating MMP of confined fluid systems. A modified PR EOS applicable for confined fluid characterization is applied to perform the EOS simulation of the vanishing interfacial tension (VIT) experiments. The MMP of multiple CO2/hydrocarbon systems at different pore sizes are obtained via the VIT simulations. Meanwhile, the multiple mixing cell (MMC) algorithm coupled with the same modified PR EOS is applied to compute the MMP for the same fluid systems. Comparison of these results to the experimental values recognize that the MMC approach has higher accuracy in determining the MMP of confined fluid systems. Moreover, nanoscale confinement results in the drastic suppression of MMP and the suppression rate increases with decreasing pore size. The drastic suppression of MMP is highly favorable for the miscible gas injection EOR in unconventional reservoirs.