Based on the Hill yield criterion, the analytical solutions of the limit load of orthotropic thick-walled pipes under pure internal pressure, bending moment and torsion are given respectively. The simplified Mises analytical solution and finite element results of limit load for isotropic thick-walled pipe are obtained. The solution verifies the reliability of the analytical solution. The paper discusses the difference of limit load of isotropic and orthotropic pipes under the conditions of pure internal pressure, pure bending moment and pure torsion moment. It is concluded that the influence of material anisotropy on the limit load is significant. The limit load of pipe under pure internal pressure is mainly determined by circumferential yield strength, pure bending is only related to axial yield strength and pure torsion moment is related to the yield strength in the 45° direction and radial yield strength.