Osteoporosis is an age-related skeletal condition characterized by low bone mineral density and deterioration of the trabecular architecture leading to increased susceptibility to fracture [1]. Wolff hypothesized that trabecular architecture adapts to have its principal material axes aligned with the principal loading directions. Regions of experimentally labeled trabecular microdamage correspond to areas of high stress and strain calculated from FEA [2]. Studying the morphology of numerically predicted regions of tissue level yielding might provide insight into the role of trabecular architecture in the strength of trabecular bone.

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