Aortic valve calcification is a degenerative disease with high prevalence, especially amongst the elderly, and is a major cause of morbidity and mortality. Ex vivo experiments has shown that aortic valve leaflets are sensitive to their mechanical environment in a magnitude dependent manner. Fluid shear stresses, specifically, has been shown to affect inflammatory and remodeling responses relevant to aortic valve calcification [1,2].
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The Congenital Bicuspid Aortic Valve Can Experience Fluid Shear Stresses Associated With Sclerosis
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Yap, CH, Saikrishnan, N, Rathan, S, Tamilselvan, G, Vasilyev, NV, & Yoganathan, AP. "The Congenital Bicuspid Aortic Valve Can Experience Fluid Shear Stresses Associated With Sclerosis." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 1219-1220. ASME. https://doi.org/10.1115/SBC2011-53926
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