Microfluidic devices deliver the promise of high throughput data output over conventional cell cultures with significantly smaller sample sizes. The 3D microenvironment of sample cells provides with a more relevant analog to the realistic nature of cells over 2D cultures. A microfluidic device of three layers to emulate the blood vessel, the basal membrane, and aggregates of tumor cells was developed using microfabrication technologies with Polydimethylsiloxane (PDMS) . Such a 3D separation of the different layers is necessary in order to understand the dynamics of tumor cells with respect to drug responses. In this study, we examine the flow patterns and transport issues in the 3D layered microfluidic device that mimicks the tumor microenvironment.
- Bioengineering Division
Simulation and Analysis of a Flow Profile and Reaction Rate Within a 3D Microfluidic Cell Culture Array
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Ahmed, AHR, Dereli Korkut, Z, Akaydin, HD, & Wang, S. "Simulation and Analysis of a Flow Profile and Reaction Rate Within a 3D Microfluidic Cell Culture Array." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT07A024. ASME. https://doi.org/10.1115/SBC2013-14737
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