Biological tissues are heterogeneous materials that may be considered mixtures of water, proteins, and cells. The large mismatch in refractive index between these constituents causes tissues to be highly turbid, diffusing light and limiting the efficacy of optical diagnostic and therapeutic techniques . Mechanical optical clearing is a technique for reducing tissue scattering and absorption using controlled tissue deformation. Mechanical optical clearing is performed using indentation to locally modify tissue optical properties, including refractive index  and reduced scattering coefficient . This effect is attributed to transient changes in tissue water distribution as a result of interstitial fluid flow due to tissue compression. In this study, we have developed a multi-domain mathematical framework for simulating mechanical optical clearing effects on tissue mechanical and optical behavior, including hyperelasticity, viscoelasticity, porous flow, and light transport. This model was then fitted to mechanical force data and used to predict experimentally measured optical transmission.
- Bioengineering Division
Coupled Poroviscoelastic and Optical Monte Carlo Simulation of Dynamic Light Transport Through Indented Soft Tissue
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Vogt, WC, & Rylander, CG. "Coupled Poroviscoelastic and Optical Monte Carlo Simulation of Dynamic Light Transport Through Indented Soft Tissue." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT36A004. ASME. https://doi.org/10.1115/SBC2013-14683
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