The transcatheter aortic valve implantation (TAVI) valve is a bioprosthetic valve within a metal stent frame. Like traditional surgical bioprosthetic valves, the TAVI valve leaflet tissue is expected to calcify and degrade over time. However, clinical studies of TAVI valve longevity are still limited. In order to indirectly assess the longevity of TAVI valves, an estimate of the mechanical wear and tear in terms of valvular deformation and strain of the leaflets under various conditions is warranted. The aim of this study was, therefore, to develop a platform for noncontact TAVI valve deformation analysis with both high temporal and spatial resolutions based on stereophotogrammetry and digital image correlation (DIC). A left-heart pulsatile in vitro flow loop system for mounting of TAVI valves was designed. The system enabled high-resolution imaging of all three TAVI valve leaflets simultaneously for up to 2000 frames per second through two high-speed cameras allowing three-dimensional analyses. A coating technique for applying a stochastic pattern on the leaflets of the TAVI valve was developed. The technique allowed a pattern recognition software to apply frame-by-frame cross correlation based deformation measurements from which the leaflet motions and the strain fields were derived. The spatiotemporal development of a very detailed strain field was obtained with a 0.5 ms time resolution and a spatial resolution of 72 μm/pixel. Hence, a platform offering a new and enhanced supplementary experimental evaluation of tissue valves during various conditions in vitro is presented.
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March 2016
Technical Briefs
A Novel Method for Optical High Spatiotemporal Strain Analysis for Transcatheter Aortic Valves In Vitro
Simon Heide-Jørgensen,
Simon Heide-Jørgensen
Department of Engineering,
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
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Sellaswasmy Kumaran Krishna,
Sellaswasmy Kumaran Krishna
Department of Engineering,
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
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Jonas Taborsky,
Jonas Taborsky
Department of Engineering,
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
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Tommy Bechsgaard,
Tommy Bechsgaard
Department of Cardiothoracic Surgery,
Aarhus University Hospital,
Aarhus N8200, Denmark
Aarhus University Hospital,
Aarhus N8200, Denmark
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Rachid Zegdi,
Rachid Zegdi
Hôpital Européen Georges Pompidou,
Service de Chirurgie Cardiovasculaire,
Paris 75015, France
Service de Chirurgie Cardiovasculaire,
Paris 75015, France
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Peter Johansen
Peter Johansen
Department of Engineering
Faculty of Science and Technology,
Aarhus University
Aarhus 8000, Denmark
e-mail: pj@eng.au.dk
Faculty of Science and Technology,
Aarhus University
Aarhus 8000, Denmark
e-mail: pj@eng.au.dk
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Simon Heide-Jørgensen
Department of Engineering,
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Sellaswasmy Kumaran Krishna
Department of Engineering,
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Jonas Taborsky
Department of Engineering,
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Faculty of Science and Technology,
Aarhus University,
Aarhus 8000, Denmark
Tommy Bechsgaard
Department of Cardiothoracic Surgery,
Aarhus University Hospital,
Aarhus N8200, Denmark
Aarhus University Hospital,
Aarhus N8200, Denmark
Rachid Zegdi
Hôpital Européen Georges Pompidou,
Service de Chirurgie Cardiovasculaire,
Paris 75015, France
Service de Chirurgie Cardiovasculaire,
Paris 75015, France
Peter Johansen
Department of Engineering
Faculty of Science and Technology,
Aarhus University
Aarhus 8000, Denmark
e-mail: pj@eng.au.dk
Faculty of Science and Technology,
Aarhus University
Aarhus 8000, Denmark
e-mail: pj@eng.au.dk
1Corresponding author.
Manuscript received May 14, 2015; final manuscript received December 30, 2015; published online January 29, 2016. Assoc. Editor: Thao (Vicky) Nguyen.
J Biomech Eng. Mar 2016, 138(3): 034504 (7 pages)
Published Online: January 29, 2016
Article history
Received:
May 14, 2015
Revised:
December 30, 2015
Citation
Heide-Jørgensen, S., Kumaran Krishna, S., Taborsky, J., Bechsgaard, T., Zegdi, R., and Johansen, P. (January 29, 2016). "A Novel Method for Optical High Spatiotemporal Strain Analysis for Transcatheter Aortic Valves In Vitro." ASME. J Biomech Eng. March 2016; 138(3): 034504. https://doi.org/10.1115/1.4032501
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