...Ning-Jiun Jan; Po-Yi Lee; Jacob Wallace; Michael Iasella; Alexandra Gogola; Bingrui Wang; Ian A. Sigal Stretch-induced collagen uncrimping underlies the nonlinear mechanical behavior of the sclera according to what is often called the process of recruitment. We recently reported experimental...

... that skin has a high Poisson's ratio, substantially decreases in volume during uniaxial tensile loading, and demonstrates collagen fiber kinematics that are not affine with local deformation. In order to better understand the mechanical basis for these properties, we constructed multiscale mechanical models...

... it. We propose a mathematical model of fibrous networks, which reproduces qualitative features of collagen gel's stress–strain response and provides insight into the key features which impact the Young's modulus of similar fibrous tissues. This model analyzes the relationship of the Young's modulus...

...Christopher E. Korenczuk; Victor H. Barocas; William J. Richardson The scar that forms after a myocardial infarction is often characterized by a highly disordered architecture but generally exhibits some degree of collagen fiber orientation, with a resulting mechanical anisotropy. When viewed...

...) and had higher collagen content (16.10 ± 3.80%) than the myocardium (SM 2 = 55.14 ± 20.49 KPa, collagen content = 10.06 ± 4.15%) in the left ventricle. The results of this study improve our understanding of the contribution of trabeculae carneae to left ventricular compliance and will be useful...

... collagen elastin ATAA are dilatations of the arterial wall that result primarily from a weakening in the middle smooth muscle layer, or media, of the artery [ 1–3 ]. Aneurysm dissection and rupture pose serious risk of mortality and are the primary concerns for patients with an ATAA [ 1–4...

...) is a rapidly fatal disease in which mortality is typically due to right ventricular (RV) failure. An excellent predictor of mortality in PAH is proximal pulmonary artery stiffening, which is mediated by collagen accumulation in hypoxia-induced pulmonary hypertension (HPH) in mice. We sought to investigate...

...Mohammad F. Hadi; Victor H. Barocas While differences in collagen fiber alignment played a role in prescribing macroscale failure outcomes, the model must be expanded to consider the role of fiber-to-fiber connectivity, intrafibrillar matrix, and multiple protein networks in order to simulate...

... a multiscale mechanical model for the failure of collagenous soft tissues that incorporates spatial heterogeneity in the microstructure and links the failure of discrete collagen fibers to the material response of the tissue. The model, which is based on experimental failure data derived from different...

...Victor K. Lai; Spencer P. Lake; Christina R. Frey; Robert T. Tranquillo; Victor H. Barocas Fibrin and collagen, biopolymers occurring naturally in the body, are biomaterials commonly-used as scaffolds for tissue engineering. How collagen and fibrin interact to confer macroscopic mechanical...

... testing microstructure mechanical collagen elastin mouse aorta two-photon multiphoton The use of genetically modified mice has proven to be a valuable addition to the study of disease etiology and treatment. Particularly, these mouse models for disease provide a means to test disease...

... to model and predict the behavior under any load. Most ex vivo tests are performed within 24 h of dissection, so the tissue is still “alive.” For large elastic arteries; however, the passive mechanical behavior is attributed mostly to the very stable proteins, elastin, and collagen. If the testing...

... biological tissues biomechanics boundary-elements methods cellular biophysics deformation elasticity encapsulation finite element analysis optimisation Young's modulus osteoarthritis collagen proteoglycan aggrecan numerical model inverse problem Mow , V. C. , Ratcliffe...

...Thomas L. Willett; Rosalind S. Labow; Ian G. Aldous; Nick C. Avery; J. Michael Lee Soft tissue injuries are poorly understood at the molecular level. Previous work using differential scanning calorimetry (DSC) has shown that tendon collagen becomes less thermally stable with rupture. However, most...

... biomedical measurement biomedical optical imaging deformation soft tissue achilles tendon fascicle biomechanical properties digital image correlation imaging polarized light collagen collagen fibers failure The gastrocnemius (Achilles) tendon connects the gastrosoleus (calf) muscle...

... of their ability to differentiate into cells of the osteoblastic lineage. Mechanical stimulation is able to promote osteogenic differentiation of hMSC; however, the use of hydrostatic pressure (HP) has not been well studied. Artificial extracellular matrices containing collagen and chondroitin sulfate (CS) have...

... with arteries under normal pulsatile pressure. Porcine carotid arteries were cultured for 3 and 7 days under normal, nonpulsatile, and hyperpulsatile pressures with the same mean pressure and flow rate using an ex vivo organ culture model. Fenestrae in the internal elastic lamina, collagen, fibronectin, and gap...

... to be responsible for the initiation of the aneurysm growth. The aneurysm is regarded as a development of the adventitia, which is composed of several distinct layers of collagen fibers perfectly aligned in specified directions. The collagen fibers are the only load-bearing constituent in the aneurysm wall...

... stress and flow-induced shear stress from their normal physiological values drives the changes in the arterial geometry. Second, the new mass that is produced during remodeling results from an increase in the mass of smooth muscle cells and collagen fibers. The model additionally accounts for the effect...

..., pp. 449–457 ) to incorporate a glycosaminoglycan (GAG)-collagen (COL) stress balance using compressible elastic stress constitutive equations specific to articular cartilage (AC). For uniaxial loading of a mixture of quasilinear VE constituents, time constant and relaxation ratio equations...