... and biomechanical forces influence disease growth. Wall shear stress (WSS) affects coronary artery atherosclerosis by inducing endothelial cell mechanotransduction and by controlling the near-wall transport processes involved in atherosclerosis. Each of these processes is controlled by WSS differently and therefore...

...Daisuke Yoshino; Masaaki Sato Blood pressure is an important factor both in maintaining body homeostasis and in its disruption. Vascular endothelial cells (ECs) are exposed to varying degrees of blood pressure and therefore play an important role in these physiological and pathological events...

...Leonie Rouleau; Joanna Rossi; Richard L. Leask Inflammation plays a key role in the development and stability of coronary plaques. Endothelial cells alter their expression in response to wall shear stress (WSS). Straight/tubular and asymmetric stenosis models were designed to study the localized...

... cells stress fiber realignment biochemomechanical model cyclic stretch The pulsatile nature of blood flow creates hemodynamic stimuli in the forms of cyclic stretch and shear in vascular endothelial cells. The stimuli modulate cytoskeletal remodeling in a manner that depends on the nature...

...Ronald P. Jean; Darren S. Gray; Alexander A. Spector; Christopher S. Chen We investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations of cell shape as cells...