Engineering geological alignment analysis of the oil and gas pipeline of Kuche region in Xinjiang is introduced as a case in this paper. Based on engineering geological analysis model, several important engineering geological factors are selected as evaluating factors, which are quantified by combining AHP and expert judgment. The calculation of engineering geological alignment analysis of pipeline is realized semi-automation based on the data management and spatial analysis functions of MAPGIS. According to the calculated engineering geological composite index, the optimized route is determined.