Recently, the demand of complex shape parts has increased in the aircraft and medical industries. In these parts machining, the displacement and vibration of workpiece that strongly affect the machining efficiency are induced due to the heavy change of the unmachined workpiece shape and stiffness during rough machining. However, it is difficult to automatically determine machining parameters of operation planning by using a commercial CAM software because there is a large number of combinations. Therefore, in order to improve the efficiency of complex parts machining, the authors proposed a determination method of workpiece shapes during rough machining based on topology optimization relevant to maximizing static stiffness. On the other hand, tool paths that directly affect the workpiece stiffness are not generated automatically to create the calculated workpiece shapes in the previous study. From these reasons, this study proposes a generation method of tool paths by using design variables obtained through the calculation of topology optimization. The tool paths are simply generated based on design variables and enables to ensure the workpiece stiffness during rough machining because design variables are strongly related to the objective function. By conducting a machining experiment assuming complex parts machining, it is confirmed that the proposed method has a potential to realize efficient rough machining.