Bone tissue engineering is an emerging field providing viable substitutes for bone regeneration. Freeform fabrication provides an effective process tool to manufacture scaffolds with complex shapes and designed properties. We developed a novel precision extruding deposition (PED) technique to fabricate composite polycaprolactone∕hydroxyapatite (PCL∕HA) scaffolds. 25% concentration by weight of HA was used to reinforce 3D scaffolds. Two groups of scaffolds having 60% and 70% porosities and with pore sizes of and respectively, were evaluated for their morphology and compressive properties using scanning electron microscopy and the mechanical testing. In vitro cell-scaffold interaction study was carried out using primary fetal bovine osteoblasts. The cell proliferation and differentiation were evaluated by Alamar Blue assay and alkaline phosphatase activity. Our results suggested that compressive modulus of PCL∕HA scaffold was for 60% porous scaffolds and was for 70% porous scaffolds. The osteoblasts were able to migrate and proliferate for the cultured time over the scaffolds. Our study demonstrated the viability of the PED process to fabricate PCL scaffolds having necessary mechanical property, structural integrity, controlled pore size, and pore interconnectivity desired for bone tissue engineering.
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e-mail: sunwei@drexel.edu
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April 2008
Research Papers
Solid Freeform Fabrication of Polycaprolactone∕Hydroxyapatite Tissue Scaffolds
L. Shor,
L. Shor
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics,
Drexel University
, Philadelphia, PA 19104
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S. Güçeri,
S. Güçeri
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics,
Drexel University
, Philadelphia, PA 19104
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M. Gandhi,
M. Gandhi
School of Biomedical Engineering, Sciences and Health System,
Drexel University
, Philadelphia, PA 19104
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X. Wen,
X. Wen
Department of Bioengineering, Cell Biology, and Orthopedic Surgery,
Clemson University
, 173 Ashley Avenue, CRI No. 610, Charleston, SC 29425
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W. Sun, Ph.D.
W. Sun, Ph.D.
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics,
e-mail: sunwei@drexel.edu
Drexel University
, Philadelphia, PA 19104
Search for other works by this author on:
L. Shor
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics,
Drexel University
, Philadelphia, PA 19104
S. Güçeri
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics,
Drexel University
, Philadelphia, PA 19104
M. Gandhi
School of Biomedical Engineering, Sciences and Health System,
Drexel University
, Philadelphia, PA 19104
X. Wen
Department of Bioengineering, Cell Biology, and Orthopedic Surgery,
Clemson University
, 173 Ashley Avenue, CRI No. 610, Charleston, SC 29425
W. Sun, Ph.D.
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics,
Drexel University
, Philadelphia, PA 19104e-mail: sunwei@drexel.edu
J. Manuf. Sci. Eng. Apr 2008, 130(2): 021018 (6 pages)
Published Online: April 11, 2008
Article history
Received:
April 18, 2007
Revised:
August 2, 2007
Published:
April 11, 2008
Citation
Shor, L., Güçeri, S., Gandhi, M., Wen, X., and Sun, W., Ph.D. (April 11, 2008). "Solid Freeform Fabrication of Polycaprolactone∕Hydroxyapatite Tissue Scaffolds." ASME. J. Manuf. Sci. Eng. April 2008; 130(2): 021018. https://doi.org/10.1115/1.2898411
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