Deep brain stimulation (DBS) has provided relief for many patients with medically refractory movement disorders. While the mechanisms involved are not entirely understood, studies have shown that continuous high-frequency DBS in the subthalamic nucleus (STN) or globus pallidus interna reduces the severity of the motor impairments in Parkinson's disease in both humans and monkeys. A limitation of present DBS approaches is the lack of feedback to control the stimulation and optimize the therapeutic outcome. Several studies have demonstrated the potential for closed-loop stimulation to tailor stimulation to the pathological state [3,4]. One critical question is the internal signals to use for feedback control. The goal of this study was to evaluate for potentially useful feedback signals recorded in MPTP-induced hemi-parkinsonian non-human primates trained in an arm reaching task. An emphasis was placed on spectral analysis of the extracellular local field potentials (LFPs) recorded in the STN, and the...

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