Deep brain stimulation (DBS) has provided relief for many patients with medically refractory movement disorders. While the mechanisms involved are not entirely understood, studies have shown that continuous high-frequency DBS in the subthalamic nucleus (STN) or globus pallidus interna reduces the severity of the motor impairments in Parkinson's disease in both humans and monkeys. A limitation of present DBS approaches is the lack of feedback to control the stimulation and optimize the therapeutic outcome. Several studies have demonstrated the potential for closed-loop stimulation to tailor stimulation to the pathological state [3,4]. One critical question is the internal signals to use for feedback control. The goal of this study was to evaluate for potentially useful feedback signals recorded in MPTP-induced hemi-parkinsonian non-human primates trained in an arm reaching task. An emphasis was placed on spectral analysis of the extracellular local field potentials (LFPs) recorded in the STN, and the...
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September 2013
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Parkinsonism State Uncouples Correlation Between Subthalamic Nucleus ß-Band Activity and Motor Performance
Laurentiu Popa,
University of Minnesota
Laurentiu Popa
Department of Neuroscience
,University of Minnesota
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Timothy J. Ebner
University of Minnesota
Timothy J. Ebner
Department of Neuroscience
,University of Minnesota
Search for other works by this author on:
Laurentiu Popa
Department of Neuroscience
,University of Minnesota
Dwight Nelson
Medtronic, Inc
Timothy J. Ebner
Department of Neuroscience
,University of Minnesota
Manuscript received March 15, 2013; final manuscript received April 29, 2013; published online July 3, 2013. Assoc. Editor: Arthur G. Erdman.
J. Med. Devices. Sep 2013, 7(3): 030906 (2 pages)
Published Online: July 3, 2013
Article history
Received:
March 15, 2013
Revision Received:
April 29, 2013
Citation
Popa, L., Gupta, R., Nelson, D., and Ebner, T. J. (July 3, 2013). "Parkinsonism State Uncouples Correlation Between Subthalamic Nucleus ß-Band Activity and Motor Performance." ASME. J. Med. Devices. September 2013; 7(3): 030906. https://doi.org/10.1115/1.4024530
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