Consider the swinging effect of spherical tank, the theory of velocity potential is adopted, and a reasonable potential function is derived according to the boundary conditions. Further, the dynamic fluid pressure, the wave height of the liquid, the shear force and the overturning moment at the bottom of the spherical tank is calculated, and a simplified dynamic model of spherical tank considering liquid sloshing and swinging effect was constructed. The seismic response was studied and compared with the results without considering the swing effect. The results show that: for Ι, II site conditions, base shear force and overturning moment of considering the swing effect is slightly smaller than when nonconsidering and the difference rate between the two is very small. III–IV site conditions, each condition value of considering the swing effect is larger than when nonconsidering and the difference rate between the two is relatively large. Aseismic design of spherical tank and the influence of swing effect should be considered if the site condition is III and IV, and if site I and II, they can be ignored.