This paper presents the design, fabrication, and characterization of a continuous flow micropump system. The system comprises two single pneumatic micropumps connected in parallel and a fluidic capacitor. It has been made of polydimethylsiloxane (PDMS). Each of the pneumatic pumps features a pump chamber, a flexible membrane, and an air chamber. The fluidic capacitor equals a single micropump without air chamber. A maximum flow rate of 496 μL/min is obtained. The influence of the fluidic capacitor is investigated at frequencies of 1 Hz and 3 Hz. The flow rate is considerably smoothened with a smoothing factor of about 0.6.
Issue Section:
Research Papers
References
1.
Demming
, S.
, Peterat
, G.
, Llobera
, A.
, Schmolke
, H.
, Bruns
, A.
, Kohlstedt
, M.
, Al-Halhouli
, A. T.
, Klages
, C.-P.
, Krull
, R.
, and Büttgenbach
, S.
, 2012
, “Vertical Microbubble Column–A Photonic Lab-on-Chip for Cultivation and Online Analysis of Yeast Cell Cultures
,” Biomicrofluidics
, 6
(3
), p. 034106
.2.
Peterat
, G.
, Schmolke
, H.
, Lorenz
, T.
, Llobera
, A.
, Rasch
, D.
, Al-Halhouli
, A. T.
, Dietzel
, A.
, Büttgenbach
, S.
, Klages
, C.-P.
, and Krull
, R.
, 2014
, “Characterization of Oxygen Transfer in Vertical Micro Bubble Columns for Biotechnological Process Intensification
,” Biotechnol. Bioeng.
, 111
(9
), pp. 1809
–1819
.3.
Demming
, S.
, 2011
, Disposable Lab-on-Chip Systems for Biotechnological Screening
, Shaker Verlag
, Aachen, Germany
, Chap. 3.4.
Al-Halhouli
, A. T.
, Kilani
, M. I.
, Waldschik
, A.
, Phataralaoha
, A.
, and Büttgenbach
, S.
, 2012
, “Development and Testing of a Synchronous Micropump Based on Electroplated Coils and Microfabricated Polymer Magnets
,” J. Micromech. Microeng.
, 22
(6
), p. 065027
.5.
Inman
, W.
, Domansky
, K.
, Serdy
, J.
, Owens
, B.
, Trumper
, D.
, and Griffith
, L. G.
, 2007
, “Design, Modelling and Fabrication of a Constant Flow Pneumatic Micropump
,” J. Micromech. Microeng.
, 17
(5
), pp. 891
–899
.6.
Yang
, B.
, and Lin
, Q.
, 2009
, “A Compliance-Based Microflow Stabilizer
,” J. Microelectromech. Syst.
, 18
(3
), pp. 539
–546
.7.
Demming
, S.
, Fadl
, A.
, Schleßmann
, M.
, Hoxhold
, B.
, Zhang
, Z.
, and Büttgenbach
, S.
, 2010
, “The Effect of Different Monolithically Integrated Check Valve Designs on the Efficiency of Disposable PZT-PDMS-Micropumps
,” ASME
Paper No. FEDSM-ICNMM2010-3120.8.
Lucas
, N.
, Demming
, S.
, Jordan
, A.
, Sichler
, P.
, and Büttgenbach
, S.
, 2008
, “An Improved Method for Double-Sided Moulding of PDMS
,” J. Micromech. Microeng.
, 18
(7
), p. 075037
.9.
Xia
, Y.
, and Whitesides
, G. M.
, 1998
, “Soft Lithography
,” Annu. Rev. Mater. Sci.
, 28
(1
), pp. 153
–184
.10.
Lorenz
, H.
, Despont
, M.
, Fahrni
, N.
, Brugger
, J.
, Vettiger
, P.
, and Renaud
, P.
, 1998
, “High-Aspect-Ratio, Ultrathick, Negative-Tone Near-UV Photoresist and Its Applications for MEMS
,” Sens. Actuators, A
, 64
(1
), pp. 33
–39
.11.
Nguyen
, N. T.
, and Wereley
, S. T.
, 2006
, Fundamentals and Applications of Microfluidics
, 2nd ed., Artech House
, Norwood, MA
.12.
Armani
, D.
, Liu
, C.
, and Aluru
, N.
, 1999
, “Re-Configurable Fluid Circuits by PDMS Elastomer Micromachining
,” 12th IEEE International Conference on Micro Electro Mechanical Systems
(MEMS '99
), Orlando, FL, Jan. 21, pp. 222
–227
.13.
Hocheng
, H.
, Chen
, C. M.
, Chou
, Y. C.
, and Liu
, C. H.
, 2010
, “Study of Novel Electrical Routing and Integrated Packaging on Bio-Compatible Substrates
,” Microsyst. Technol.
, 16
(3
), pp. 423
–430
.14.
Zengerle
, R.
, and Richter
, M.
, 1994
, “Simulation of Microfluid Systems
,” J. Micromech. Microeng.
, 4
(4
), pp. 192
–204
.15.
Domansky
, K.
, Inman
, W.
, Serdy
, J.
, and Griffith
, L. G.
, 2006
, “Multiwell Cell Culture Plate Format With Integrated Microfluidic Perfusion System
,” Proc. SPIE
6112
, p. 61120F
.16.
Lee
, P. J.
, Hung
, P. J.
, Rao
, V. M.
, and Lee
, L. P.
, 2006
, “Nanoliter Scale Microbioreactor Array for Quantitative Cell Biology
,” Biotechnol. Bioeng.
, 94
(1
), pp. 5
–14
.17.
Hung
, P. J.
, Lee
, P. J.
, Sabounchi
, P.
, Lin
, R.
, and Lee
, L. P.
, 2005
, “Continuous Perfusion Microfluidic Cell Culture Array for High-Throughput Cell-Based Assays
,” Biotechnol. Bioeng.
, 89
(1
), pp. 1
–8
.18.
Leclerc
, E.
, Sakai
, Y.
, and Fujii
, T.
, 2004
, “Microfluidic PDMS (Polydimethylsiloxane) Bioreactor for Large-Scale Culture of Hepatocytes
,” Biotechnol. Prog.
, 20
(3
), pp. 750
–755
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