Two types of liquid hole-pattern seals with axially oblique (A-HPS) or circumferentially oblique (C-HPS) hole cavities are designed. To evaluate the leakage and rotordynamic characteristics of the liquid hole-pattern seals, a 3D transient perturbation method is employed, which based on the multifrequency one-dimensional rotor whirling model and the mesh deformation technique. The accuracy and reliability of the proposed numerical approach is demonstrated based on the published experimental data of the leakage and rotordynamic force coefficients for a hole-pattern seal (HPS). Seal leakage and force coefficients are presented and compared for the A-HPS (axially oblique angle ), C-HPS (circumferentially oblique angle ), and HPS (α = 0, β = 0) at various rotational speeds (n = 0.05, 2.0, 4.0, and 6.0 krpm). Results reveal that the tilted hole cavity with positive α or β can reduce the seal effective clearance and strengthen the kinetic dissipation in hole cavities, yielding less leakage by 5–10%, especially at higher rotational speeds. The tilted hole cavity with a positive oblique angle results in a moderate growth (by ∼6% for the A-HPS, by ∼15% for C-HPS) in the effective stiffness. Furthermore, the tilted hole cavity shows a very weak influence (<4.0%) on the effective damping, particularly for higher rotational speeds and vibration frequencies. Considering the decreasing leakage and nonworse rotordynamic characteristics, a tilted hole cavity with suitable positive oblique angles is beneficial for the liquid hole-pattern seal.